This study was planned to evaluate clinic-pathological effects occurring on short term oral ethanol administration in Wistar rats. The study comprised of four groups consisting of 5 female wistar rats in each group. Ethanol was administered orally for ten consecutive days to three treatment groups at dose rate of 2% (v/v), 4% (v/v) and 10% (v/v) and the control group was administered with distilled water as vehicle at the dose rate of 5 ml/kg body weight. Parameters evaluated in this study included in-life observations and measurements, post treatment clinical chemistry investigations, post treatment organ weight estimations. All animals were well tolerated with ethanol treatment without any mortality and clinical signs till the end of the treatment period. Significant decrease in body weight was observed at dose level of 4% and 10% (v/v) on day 7 and day 10 of treatment period in ethanol treated rats compared to concurrent control group of animals. Feed consumption was comparatively less in ethanol treated group of animals compared to concurrent control group. Significant increase in serum SGPT and Total cholesterol were observed at dose level of 4% and 10% (v/v) in ethanol treated group. Similarly significant increase in ALP, Triglyceride, Uric acid at dose level of 10% (v/v) in ethanol treated group. On the other hand significant decrease in Urea level was observed at dose level of 10% (v/v) in ethanol treated animals as compared to concurrent control group. Significant increase in liver weight was observed at dose levels of 10% (v/v) in ethanol treated group. Kidney weight was significantly increased in ethanol treated groups at dose level of 4% and 10% (v/v). Similarly reducing trend in spleen, adrenals and thymus absolute weight were observed in ethanol treated rats compared to concurrent control group of animals. These study findings were suggestive of adverse clinic-pathology occurring on short term oral administration of ethanol in rats.
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